Towards the end of the 1990s we conducted a comparative study in 19 patients with advanced head and neck cancer. We evaluated 2 groups: one with neoadjuvant CT (before commencing RT and concurrent 5-fluorouracil) and the other group without neoadjuvant CT but with O3T (by autohemotherapy method) during concurrent RT and 5-fluorouracil. Both patient groups had the same median survival (8 months) despite the fact that the group treated with ozone had included significantly higher numbers of patients with more adverse prognostic factors such as older age, larger size of metastatic cervical adenopathies, and higher percentage of patients with metastases at distance .
In 2012, a report on 40 patients with advanced non-small cell lung cancer was communicated. The patients were treated with and without concomitant O3T by autohemotherapy (once a week for 12 weeks) and subcutaneous injection of Viscum album fermentatum (a species of mistletoe, a phytocompound used in northern Europe since Celtic times). Patients treated simultaneously with ozone and extracts of Viscum album showed a significantly better quality-of-life score measured by the quality-of-life questionnaire-core 30 (QLQ-C30). Additionally, this patient group showed a significant decrease in plasma values of reactive species metabolites and an increase in biological antioxidant potential . 1e1e36bf2d